What Is Fragile X Syndrome?

Fragile X syndrome is the most common inherited cause of intellectual disability and the leading known single-gene cause of autism. It is caused by a mutation in the FMR1 gene on the X chromosome. The syndrome affects approximately 1 in 4,000 males and 1 in 8,000 females.

People with Fragile X syndrome may experience intellectual disability, developmental delays, learning disabilities, and anxiety. Symptoms vary widely — some individuals are mildly affected, others more significantly. There is currently no cure, though therapies and supportive care can improve quality of life.

Fragile X is also the most common known cause of autism spectrum disorder. An estimated 1 in 151 women and 1 in 468 men carry the FMR1 premutation — often without knowing it. Carriers can pass Fragile X to their children.

Our Connection

Green Tree Jewelry is a family company. Fragile X is part of our family's story. We support awareness because most people — including many carriers — have never heard of it.

Learn More and Get Support

For research updates, family resources, and support programs, visit:

• FRAXA Research Foundation — funding research toward treatments and a cure
• National Fragile X Foundation — education, advocacy, and family support